Anima is an ancient Horror is an ancient giant Horror of great power, resembling a headless human female with shiny blue skin and mouths on the palm of her hands.
Long ago, Anima was sealed beneath the Valiante Kingdom by the Makai Order. Years before the events of GARO: The Carved Seal of Flames, Mendoza schemed to revive the Horror to obtain immortality. This plot involved Mendoza engineering his conquest of Valiante and creating a crucifix-shaped crystal composed of the souls of countless Makai practitioners that were killed in his witch hunt. The Watchdog Garm intends to allow Mendoza to carry out his plan, sending the remaining Makai Knights and Alchemists to Santa Bard via the Watchdog Center to thin out the Horrors' numbers despite the inevitable total destruction of Santa Bard and countless human deaths that would result from such a plan. Anima is eventually revived with the crucifix-shaped crystal embedded through her torso. Anima is later absorbed by Mendoza.
Anima combines traits of previous final enemy Horrors from the live action installments: Messiah and Eyrith due to their naked appearances and Zedom for being a Horror that buried under an area of land that is built into a populated area where events of the story take place in.